Hi,欢迎来到雅吉生物商城,请 登录 / 注册
关注我们
服务热线
021-34661275
购物车
0
当前位置: 首页 > 抗体 > 抗体 > 诱导协同刺激分子CD278抗体
诱导协同刺激分子CD278抗体
  • 英文名:ICOS
  • 纯   度:1mg/ml
  • 存储条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品货号 产品规格 产品价格 数量 加入购物车 咨询客服
2583R 50ul 980.00 加入购物车 咨询客服
  • 产品描述

  • 注意事项

  • 参考文献

  • 相关产品

 英文名称ICOS

中文名称诱导协同刺激分子CD278抗体
别    名Activation inducible lymphocyte immunomediatory molecule; Activation-inducible lymphocyte immunomediatory molecule; AILIM; CD278; CD278 antigen; CVID1; ICOS; ICOS_HUMAN; Inducible costimulator; Inducible T cell co stimulator; Inducible T-cell costimulator; MGC39850.  
研究领域细胞生物  免疫学  细胞膜受体  t-淋巴细胞  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, 
产品应用WB=1:500-2000 ELISA=1:500-1000  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量20kDa
细胞定位细胞膜 分泌型蛋白 
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ICOS:51-150/199 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍 The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.[provided by RefSeq, Jul 2008].
 
Function:
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). 
 
Subunit:
Homodimer; disulfide-linked.
 
Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential).Isoform 2: Secreted (Potential).
 
Tissue Specificity:
Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
 
Post-translational modifications:
N-glycosylated.
 
DISEASE:
Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1) [MIM:607594]. CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo.
 
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
 
SWISS:
Q9Y6W8
 
Gene ID:
29851
 
Database links:
Entrez Gene: 29851 Human
 
Entrez Gene: 54167 Mouse
 
Entrez Gene: 64545 Rat
 
Omim: 604558 Human
 
SwissProt: Q9Y6W8 Human
 
SwissProt: Q9WVS0 Mouse
 
SwissProt: Q9R1T7 Rat
 
Unigene: 56247 Human
 
Unigene: 42044 Mouse
 
Unigene: 168816 Rat
 
 
 
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
  • 品质保证
    诚信经营 购物无忧
  • 在线客服
    在线贴心服务
  • 免费包邮
    在线订单满188免邮费
  • 会员服务
    享受优惠和积分
© Copyright 上海雅吉生物有限公司 All Rights Reserved. 备案号:沪ICP备123456号-0